Hispanics/Latinos are the largest ethnic/racial group in the United States and at high risk for Alzheimer's disease and related dementia (ADRD). Yet, ADRD among diverse Latinos is poorly understood and disparately understudied or unstudied compared to other ethnic/racial groups that leave the nation ill‐prepared for major demographic shifts that lay ahead in coming decades. The primary purpose of this Perspectives article was to provide a new research framework for advancing Latino ADRD knowledge, encompassing the unique sociocultural, cardiometabolic, and genomic aspects of Latino health, aging, and ADRD. In addition, we describe some of the research challenges to progress in Latino ADRD research. Finally, we present the Study of Latinos – Investigation of Neurocognitive Aging (SOL‐INCA) as an example of implementing this new framework for advancing Latino ADRD research.

中文翻译：

---

美国不同拉丁裔人群认知衰老和阿尔茨海默病的研究框架：西班牙裔社区健康研究/拉丁裔研究——神经认知衰老调查 (SOL-INCA) 的设计和实施

西班牙裔/拉丁裔是美国最大的族裔/种族群体，他们患阿尔茨海默病和相关痴呆症 (ADRD) 的风险很高。然而，与其他种族/种族群体相比，不同的拉丁裔人群中的 ADRD 知之甚少，研究也不尽相同，这些群体使该国对未来几十年的重大人口结构变化准备不足。这篇观点文章的主要目的是为推进拉丁裔 ADRD 知识提供一个新的研究框架，包括拉丁裔健康、衰老和 ADRD 的独特社会文化、心脏代谢和基因组方面。此外，我们描述了拉丁裔 ADRD 研究进展的一些研究挑战。最后，