Reactivation of human herpesvirus (HHV)-6B is relatively common after allogeneic hematopoietic stem cell transplantation (HSCT) and HHV-6B diseases may consequently develop. Among them, HHV-6B encephalitis is a serious and often fatal complication. The aim of these clinical practice recommendations is to provide diagnostic and therapeutic guidance for HHV-6B encephalitis after allogeneic HSCT. In this evidence-based review, we critically evaluated data from the published literature. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assist in generating recommendations. We have summarized the findings that contribute to decision-making and we have provided our recommendations. In cases where rigorous clinical data are unavailable, recommendations have been developed in discussions with physicians who have relevant expertize.

在异基因造血干细胞移植（HSCT）之后，人类疱疹病毒（HHV）-6B的重新激活相对普遍，因此可能会发展出HHV-6B疾病。其中，HHV-6B脑炎是一种严重的且常常是致命的并发症。这些临床实践建议的目的是为同种异体造血干细胞移植术后的HHV-6B脑炎提供诊断和治疗指导。在此基于证据的综述中，我们对发表的文献中的数据进行了严格的评估。建议的评估，开发和评估分级（GRADE）方法用于协助生成建议。我们总结了有助于决策的发现，并提供了建议。如果没有严格的临床数据，