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TSLP: from allergy to cancer.
Nature Immunology ( IF 27.7 ) Pub Date : 2019-11-19 , DOI: 10.1038/s41590-019-0524-9
Jonathan Corren 1 , Steven F Ziegler 2
Affiliation  

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 immune responses has been investigated extensively, recent studies have found an expanding role for TSLP in inflammatory diseases and cancer. In this Review, we will highlight major recent advances in TSLP biology, along with results from emerging clinical trials of anti-TSLP agents used for the treatment of a variety of inflammatory conditions.

中文翻译:

TSLP:从过敏到癌症。

细胞因子 TSLP 已被证明是维持免疫稳态和调节粘膜屏障炎症反应的关键因素。虽然 TSLP 在 2 型免疫反应中的作用已被广泛研究,但最近的研究发现 TSLP 在炎症性疾病和癌症中的作用正在扩大。在这篇综述中,我们将重点介绍 TSLP 生物学的最新进展,以及用于治疗各种炎症性疾病的抗 TSLP 药物的新兴临床试验结果。
更新日期:2019-11-20
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