IL-17 receptor-based signaling and implications for disease.,Nature Immunology

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IL-17 receptor-based signaling and implications for disease.
Nature Immunology ( IF 27.7 ) Pub Date : 2019-11-19 , DOI: 10.1038/s41590-019-0514-y
Xiaoxia Li ₁ , Rami Bechara ₂ , Junjie Zhao ₁ , Mandy J McGeachy ₂ , Sarah L Gaffen ₂

Affiliation

IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the progression of cancer. In contrast to its profound impact in vivo, IL-17 exhibits surprisingly moderate activity in cell-culture models, which presents a major knowledge gap about the molecular mechanisms of IL-17 signaling. Emerging studies are revealing a new dimension of complexity in the IL-17 pathway that may help explain its potent and diverse in vivo functions. Discoveries of new mRNA stabilizers and receptor-directed mRNA metabolism have provided insights into the means by which IL-17 cooperates functionally with other stimuli in driving inflammation, whether beneficial or destructive. The integration of IL-17 with growth-receptor signaling in specific cell types offers new understanding of the mitogenic effect of IL-17 on tissue repair and cancer. This Review summarizes new developments in IL-17 signaling and their pathophysiological implications.

中文翻译：

基于 IL-17 受体的信号传导和对疾病的影响。

IL-17 是一种高度通用的促炎细胞因子，对多种过程至关重要，包括宿主防御、组织修复、炎性疾病的发病机制和癌症的进展。与其在体内的深远影响相反，IL-17 在细胞培养模型中表现出令人惊讶的中等活性，这提出了关于 IL-17 信号传导的分子机制的主要知识空白。新兴研究揭示了 IL-17 通路复杂性的一个新维度，这可能有助于解释其强大而多样的体内功能。新的 mRNA 稳定剂和受体导向的 mRNA 代谢的发现提供了对 IL-17 与其他刺激在驱动炎症（无论是有益的还是破坏性的）功能上协同作用的方式的见解。IL-17 与特定细胞类型中生长受体信号传导的整合提供了对 IL-17 对组织修复和癌症的促有丝分裂作用的新认识。本综述总结了 IL-17 信号传导的新进展及其病理生理学意义。

更新日期：2019-11-20

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