Early oral colostrum administration in preterm infants.,Journal of Perinatology

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Early oral colostrum administration in preterm infants.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-11-20 , DOI: 10.1038/s41372-019-0556-x
Diana Maffei ₁ , Mariana Brewer ₁ , Champa Codipilly ₁ , Barry Weinberger ₁ , Richard J Schanler ₁

Affiliation

BACKGROUND Early administration of colostrum may provide preterm infants with immune components. Previous studies illustrating the effects of oral colostrum (OC) have been confounded by the coincidence of enteral feedings. OBJECTIVE To quantify OC absorption, as measured by urinary sIgA and lactoferrin, in preterm infants prior to enteral feedings. MATERIALS AND METHODS Colostrum was obtained from mothers delivering infants ≤32 weeks and ≤1500 g. sIgA and lactoferrin were measured in infant urine, and microflora in saliva and tracheal aspirates were characterized. RESULTS Urinary sIgA and lactoferrin were significantly greater in infants receiving OC by syringe compared to swab (p < 0.002). Urinary sIgA correlated with the total number of doses in 72 h (R2 = 43%, p < 0.01). CONCLUSIONS Administration of OC by syringe and higher cumulative dose are associated with increased absorption of sIgA and lactoferrin, and early dosing may contribute to a more diverse tracheal microbiome.

中文翻译：

早产儿口服早期牛初乳。

背景技术初乳的早期给药可以为早产儿提供免疫成分。先前的研究表明口服初乳（OC）的影响已被肠内喂养的巧合所混淆。目的通过肠道sIgA和乳铁蛋白定量测定肠内喂养前早产儿的OC吸收。材料和方法初乳是从分娩≤32周且≤1500g的母亲那里获得的。在婴儿尿液中测量了sIgA和乳铁蛋白，并对唾液和气管抽吸物中的菌群进行了表征。结果与通过拭子相比，通过注射器接受OC的婴儿的尿中sIgA和乳铁蛋白显着更高（p <0.002）。尿sIgA与72小时内的总剂量相关（R2 = 43％，p <0.01）。

更新日期：2019-11-20

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