Generativity, or concern for and contribution to the well-being of younger generations, plays an important role in successful aging. The purpose of this study was to develop a novel, writing-based intervention to increase feelings of generativity and test the effect of this intervention on well-being and inflammation in a sample of older women. Participants in this study (n=73; mean age = 70.9 years, range 60-86 years) were randomly assigned to a 6-week generativity writing condition (writing about life experiences and sharing advice with others) or a control writing condition (neutral, descriptive writing). Self-reported measures of social well-being, mental health, and physical health, as well as objective measures of systemic and cellular levels of inflammation (plasma pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α; genome-wide RNA transcriptional profiling), were assessed pre- and post-intervention. The generativity intervention led to significant improvements across multiple domains, including increases in participation in social activities, decreases in psychological distress, more positive expectations regarding aging in the physical health domain, and decreases in pro-inflammatory gene expression. Thus, this study provides preliminary evidence for the ability of a novel, low-cost, low-effort intervention to favorably impact inflammation and well-being in older women.

中文翻译：

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需要的感觉：随机生成干预对老年女性健康和炎症的影响

生育能力，或对年轻一代福祉的关注和贡献，在成功老龄化方面发挥着重要作用。本研究的目的是开发一种新颖的、基于写作的干预措施，以增加生殖感，并测试这种干预措施对老年女性样本的幸福感和炎症的影响。本研究的参与者（n = 73；平均年龄 = 70.9 岁，范围 60-86 岁）被随机分配到 6 周的创生写作条件（写下生活经历并与他人分享建议）或控制写作条件（中性，描述性写作）。社会福祉、心理健康和身体健康的自我报告测量，以及炎症系统和细胞水平的客观测量（血浆促炎细胞因子白细胞介素-6和肿瘤坏死因子-α；全基因组 RNA 转录谱），在干预前和干预后进行了评估。生殖干预导致多个领域的显着改善，包括社会活动参与度的增加、心理困扰的减少、对身体健康领域衰老的更积极预期以及促炎基因表达的减少。因此，这项研究为新型、低成本、省力干预对老年女性的炎症和健康产生有利影响的能力提供了初步证据。对身体健康领域的衰老和促炎基因表达的降低有更积极的期望。因此，这项研究为新型、低成本、省力干预对老年女性的炎症和健康产生有利影响的能力提供了初步证据。对身体健康领域的衰老和促炎基因表达的降低有更积极的期望。因此，这项研究为新型、低成本、省力干预对老年女性的炎症和健康产生有利影响的能力提供了初步证据。