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Curcumin analog CUR5-8 ameliorates nonalcoholic fatty liver disease in mice with high-fat diet-induced obesity.
Metabolism ( IF 10.8 ) Pub Date : 2019-11-20 , DOI: 10.1016/j.metabol.2019.154015
Eun Soo Lee 1 , Mi-Hye Kwon 2 , Hong Min Kim 1 , Ho Bum Woo 3 , Chan Mug Ahn 3 , Choon Hee Chung 1
Affiliation  

OBJECTIVE Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat storage in the liver and it is strongly linked with metabolic syndrome including obesity, insulin resistance, dyslipidemia and hypertension. Curcumin5-8 (CUR5-8) is a synthetic derivative of naturally active curcumin (CUR) that has anti-oxidative and anti-inflammatory properties. In the present study, we investigated the effects of CUR5-8, a novel CUR analog, on hepatic steatosis in mice with high-fat diet (HFD)-induced obesity. METHODS Based on their diets for 13 weeks, the mice were categorized into the following six groups: regular diet (RD, n = 10), RD with CUR (RD + CUR, 100 mg/kg/day, n = 10), RD with CUR5-8 (RD + CUR5-8, 100 mg/kg/day, n = 10), high-fat diet-induced obese mice (HFD, n = 10), HFD with CUR (HFD + CUR, 100 mg/kg/day, n = 10), and HFD with CUR5-8 (HFD + CUR5-8, 100 mg/kg/day, n = 10) for 13 weeks. Hematoxylin and eosin (H&E) staining of the sections revealed hepatic steatosis. RESULTS CUR5-8 administration prevented increase in body and liver weights in mice with HFD-induced obesity. Compared to the HFD group, insulin resistance was significantly improved in the HFD + CUR5-8 group. Serum alanine aminotransferase level, which is an indicator of liver damage, was also decreased after CUR5-8 administration. H&E staining revealed that CUR5-8 treatment decreased hepatic steatosis in mice with HFD-induced obesity. Interestingly, CUR5-8, and not CUR, decreased the elevated liver triglyceride level induced by the HFD. CONCLUSIONS These findings suggest that CUR5-8 ameliorates insulin resistance and hepatic steatosis in mice with HFD-induced obesity.

中文翻译:

姜黄素类似物CUR5-8可改善高脂饮食诱导的肥胖症小鼠的非酒精性脂肪肝疾病。

目的非酒精性脂肪性肝病(NAFLD)发生于肝脏中过多的脂肪储存,并且与代谢综合征(包括肥胖症,胰岛素抵抗,血脂异常和高血压)密切相关。姜黄素5-8(CUR5-8)是天然活性姜黄素(CUR)的合成衍生物,具有抗氧化和抗炎特性。在本研究中,我们调查了新型CUR类似物CUR5-8对高脂饮食(HFD)诱发的肥胖小鼠肝脂肪变性的影响。方法根据13周的饮食,将小鼠分为以下六组:常规饮食(RD,n = 10),RD加CUR(RD + CUR,100 mg / kg /天,n = 10),RD CUR5-8(RD + CUR5-8,100 mg / kg / day,n = 10),高脂饮食诱导的肥胖小鼠(HFD,n = 10),HFD CUR(HFD + CUR,100 mg /公斤/天,n = 10),以及使用CUR5-8(HFD + CUR5-8,100 mg / kg /天,n = 10)进行HFD治疗13周。苏木精和曙红(H&E)切片显示肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。100 mg / kg / day,n = 10),持续13周。苏木精和曙红(H&E)切片显示肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。100 mg / kg / day,n = 10),持续13周。苏木精和曙红(H&E)切片显示肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。E)切片的染色显示肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。E)切片的染色显示肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。结果CUR5-8给药可防止HFD引起的肥胖小鼠体重和肝脏重量增加。与HFD组相比,HFD + CUR5-8组的胰岛素抵抗显着改善。CUR5-8给药后,血清丙氨酸转氨酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。CUR5-8给药后,血清丙氨酸氨基转移酶水平降低,这是肝脏损害的指标。H&E染色显示,CUR5-8治疗可降低HFD诱发肥胖小鼠的肝脂肪变性。有趣的是,CUR5-8而非CUR降低了由HFD引起的肝甘油三酸酯水平升高。结论这些发现表明CUR5-8改善了HFD引起的肥胖症小鼠的胰岛素抵抗和肝脂肪变性。
更新日期:2019-11-20
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