当前位置：
X-MOL 学术
›
Exp. Neurol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions.
Experimental Neurology ( IF 4.6 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.expneurol.2019.113118 Benjamin Ongnok 1 , Nipon Chattipakorn 1 , Siriporn C Chattipakorn 2
Experimental Neurology ( IF 4.6 ) Pub Date : 2019-11-19 , DOI: 10.1016/j.expneurol.2019.113118 Benjamin Ongnok 1 , Nipon Chattipakorn 1 , Siriporn C Chattipakorn 2
Affiliation
|
Chemotherapy has significantly increased the number of cancer survivors. However, chemotherapy itself carries various adverse effects that limit the efficacy of treatment and quality of life of the cancer patients. Most patients who have received chemotherapy report some cognitive deficit characterized by dysfunction in memory, learning, concentration, and reasoning. The phenomenon of cognitive decline developed from chemotherapy treatment is referred to as chemotherapy-induced cognitive impairment (CICI) or chemobrain. The two most common cancers occurring worldwide are lung and breast cancer. The predominant chemotherapeutic drugs used to treat lung and breast cancer are doxorubicin and cisplatin. There is evidence to suggest that both drugs potentially induce chemobrain. The evidence around the proposed pathogenesis of chemobrain caused by these two drugs is inconsistent. Understanding the underlying mechanisms involved in the development of chemobrain would aid in the prevention or treatment of the adverse effects of chemotherapy on brain. This review will summarize and discuss controversial findings and possible mechanisms involved in the development of chemobrain and the interventions which could limit it from in vitro, in vivo, and clinical studies.
中文翻译：
阿霉素和顺铂引起的认知障碍：可能的机制和干预措施。
化学疗法显着增加了癌症幸存者的数量。然而，化学疗法本身带有各种不良反应，这些不良反应限制了癌症患者的治疗效果和生活质量。大多数接受过化疗的患者均报告有一些认知缺陷，其特征是记忆力，学习能力，注意力和推理功能障碍。由化学疗法治疗引起的认知能力下降的现象称为化学疗法诱发的认知障碍（CICI）或化学障碍。世界范围内发生的两种最常见的癌症是肺癌和乳腺癌。用于治疗肺癌和乳腺癌的主要化疗药物是阿霉素和顺铂。有证据表明这两种药物都可能诱导趋化性。围绕这两种药物引起的趋化性发病机制的证据不一致。了解发生化学障碍的潜在机制将有助于预防或治疗化学疗法对大脑的不良影响。这篇综述将总结和讨论有争议的发现以及与化学性脑梗阻有关的可能机制，以及可能在体外，体内和临床研究中对其加以限制的干预措施。
更新日期：2019-11-20
中文翻译：
阿霉素和顺铂引起的认知障碍：可能的机制和干预措施。
化学疗法显着增加了癌症幸存者的数量。然而，化学疗法本身带有各种不良反应，这些不良反应限制了癌症患者的治疗效果和生活质量。大多数接受过化疗的患者均报告有一些认知缺陷，其特征是记忆力，学习能力，注意力和推理功能障碍。由化学疗法治疗引起的认知能力下降的现象称为化学疗法诱发的认知障碍（CICI）或化学障碍。世界范围内发生的两种最常见的癌症是肺癌和乳腺癌。用于治疗肺癌和乳腺癌的主要化疗药物是阿霉素和顺铂。有证据表明这两种药物都可能诱导趋化性。围绕这两种药物引起的趋化性发病机制的证据不一致。了解发生化学障碍的潜在机制将有助于预防或治疗化学疗法对大脑的不良影响。这篇综述将总结和讨论有争议的发现以及与化学性脑梗阻有关的可能机制，以及可能在体外，体内和临床研究中对其加以限制的干预措施。
京公网安备 11010802027423号