Aberrant activation of Wnt/β-catenin signaling, an activity that is critically modulated by porcupine, a membrane-bound O-acyltransferase, is profibrotic. Previously, the Crowley laboratory demonstrated that oral administration of porcupine inhibitor attenuated experimental mouse kidney fibrosis. Now Lu et al., from that laboratory, using conditional knockout lineages, have shown that porcupine in the renal tubule accelerated fibrosis and Wnt generation, whereas myeloid cell porcupine counteracted the effect. Thus, porcupine has been attracting both positive and negative attention.

中文翻译：

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豪猪肾纤维化的困境。

Wnt/β-连环蛋白信号的异常激活是一种由豪猪（一种膜结合的 O-酰基转移酶）严格调节的活动，它是促纤维化的。此前，克劳利实验室证明，口服豪猪抑制剂可减轻实验性小鼠肾纤维化。现在卢等人。来自那个实验室，使用条件性敲除谱系表明，豪猪在肾小管中加速了纤维化和 Wnt 的产生，而骨髓细胞豪猪抵消了这种影响。因此，豪猪一直受到正面和负面的关注。