Membranous nephropathy and anti–glomerular basement membrane glomerulonephritis are characterized by the deposition of antibodies that recognize specific glomerular epitopes. These antibodies may develop in autoimmune diseases, after exposure to new antigens or after passive maternal transfer, such as in neonatal membranous nephropathy secondary to in utero transfer of anti–neutral endopeptidase protein Igs. In this issue of Kidney International, Abrahamson et al. reported a murine model of passive anti–glomerular basement membrane disease caused by antibody transfer from pregnant mice to their offspring.

中文翻译：

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一种新的抗GBM疾病小鼠模型揭示了肾小球疾病中同种抗体的母体转移。

膜性肾病和抗肾小球基底膜肾小球性肾炎的特点是可识别特定肾小球表位的抗体沉积。这些抗体可能会在自身免疫性疾病中，暴露于新抗原后或在母体被动转移后产生，例如在子宫中转移抗中性内肽酶蛋白Igs继发的新生儿膜性肾病中。在本期《肾脏国际》中，亚伯拉罕森等人。报道了一种由抗体从怀孕小鼠转移到其后代引起的被动抗肾小球基底膜疾病的小鼠模型。