Is there any difference in sensitivity to kidney function between men and women? Paterson et al. have focused on sex differences in chronic kidney disease. Surprisingly, their experimental results show that only one microRNA, miR-146b-5p, affected the susceptibility of renocardiac pathology. They generated miR-146b knockout rats and found that miR-146b^−/− females developed exacerbated renal hypertrophy and fibrosis and had less cardiac remodeling. Although miR-146b-5p has been reported to be upregulated in various types of cancers, this article reveals the novel role of miR-146b in the kidney.

中文翻译：

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女性比男性更容易患肾功能不全吗？

男女对肾功能的敏感性是否有差异？帕特森（Paterson）等人。专注于慢性肾脏疾病的性别差异。出乎意料的是，他们的实验结果表明，只有一种microRNA miR-146b-5p影响了肾脏病变的易感性。他们产生了miR-146b基因敲除大鼠，发现miR-146b ^-/-雌性大鼠肾脏肾肥大和纤维化加剧，心脏重塑较少。尽管据报道miR-146b-5p在各种类型的癌症中均被上调，但本文揭示了miR-146b在肾脏中的新作用。