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Novel Sensing Assembly Comprising Engineered Gold Dendrites and MWCNT‐AuNPs Nanohybrid for Acetaminophen Detection in Human Urine
Electroanalysis ( IF 2.7 ) Pub Date : 2019-11-19 , DOI: 10.1002/elan.201900551 Buddhadev Purohit 1 , Ashutosh Kumar 1 , Kuldeep Mahato 1 , Pranjal Chandra 1
Electroanalysis ( IF 2.7 ) Pub Date : 2019-11-19 , DOI: 10.1002/elan.201900551 Buddhadev Purohit 1 , Ashutosh Kumar 1 , Kuldeep Mahato 1 , Pranjal Chandra 1
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A layered nanohybrid comprising of multi walled carbon nanotubes(MWCNT)‐gold nanoparticles (AuNPs) has been designed as a matrix for the development of Au dendritic nanostructures (AuDN) with enhanced catalytic activity. The developed sensor matrix was thoroughly characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), and energy dispersive X‐ray spectroscopy (EDX). The developed sensor probe MWCNT‐AuNPs/AuDN over glassy carbon electrode (GCE) was used for the label free detection of acetaminophen (AP), a commonly used drug associated with hepatotoxicity when overdosed, as a model molecule. The final sensor probe was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), linear sweep voltammetry (LSV), and differential pulse voltammetry (DPV). The sensor shows excellent analytical performances with a linear dynamic range (LDR) of 100 to 7500 nM, and a low limit of detection (LOD) of 2.12 (±0.03) nM, which is better than recently reported AP sensors. The practical application / clinical possibilities of the final sensor were evaluated by real sample analysis in human urine by spike and recovery method, where the AP recoveries were found in between 92 % to 96 %. The sensor probe shows negligible response towards co‐existing interfering molecules like glucose, urea, uric acid and various amino acids, which are commonly found in real samples (p<0.001, n=3). The shelf life of the sensor probe was evaluated and found to be stable for 8 weeks. The fabricated sensor probe using MWCNT‐AuNPs/AuDN is easy to fabricate, simple, robust, and able to detect AP in urine with high recoveries shows its possibilities to be used in clinical settings.
中文翻译：
新型传感组件，包含工程化金枝晶和MWCNT-AuNPs纳米杂交体，用于人类尿液中对乙酰氨基酚的检测。
由多壁碳纳米管（MWCNT）-金纳米颗粒（AuNPs）组成的层状纳米杂化物已被设计为开发具有增强催化活性的金树突状纳米结构（AuDN）的基质。通过扫描电子显微镜（SEM），透射电子显微镜（TEM）和能量色散X射线光谱仪（EDX）对已开发的传感器矩阵进行了全面表征。玻碳电极（GCE）上开发的传感器探针MWCNT-AuNPs / AuDN用于无标记的对乙酰氨基酚（AP）的检测，对乙酰氨基酚（AP）是过量使用时与肝毒性相关的常用药物，作为模型分子。最终的传感器探头通过循环伏安法（CV），电化学阻抗谱（EIS），线性扫描伏安法（LSV）和差分脉冲伏安法（DPV）进行了表征。该传感器具有出色的分析性能，线性动态范围（LDR）为100到7500 nM，检测下限（LOD）为2.12（±0.03）nM，这比最近报道的AP传感器要好。最终传感器的实际应用/临床可能性通过加标和回收法对人尿液中的真实样品进行了评估，发现AP回收率在92％至96％之间。传感器探针对共存的干扰分子（如葡萄糖，尿素，尿酸和各种氨基酸）的响应微不足道，而这些干扰分子通常在真实样品中发现（p <0.001，n = 3）。评估了传感器探针的保质期，发现其稳定了8周。使用MWCNT-AuNPs / AuDN制作的传感器探头易于制造，简单，坚固，
更新日期：2019-11-20
中文翻译：
新型传感组件，包含工程化金枝晶和MWCNT-AuNPs纳米杂交体，用于人类尿液中对乙酰氨基酚的检测。
由多壁碳纳米管（MWCNT）-金纳米颗粒（AuNPs）组成的层状纳米杂化物已被设计为开发具有增强催化活性的金树突状纳米结构（AuDN）的基质。通过扫描电子显微镜（SEM），透射电子显微镜（TEM）和能量色散X射线光谱仪（EDX）对已开发的传感器矩阵进行了全面表征。玻碳电极（GCE）上开发的传感器探针MWCNT-AuNPs / AuDN用于无标记的对乙酰氨基酚（AP）的检测，对乙酰氨基酚（AP）是过量使用时与肝毒性相关的常用药物，作为模型分子。最终的传感器探头通过循环伏安法（CV），电化学阻抗谱（EIS），线性扫描伏安法（LSV）和差分脉冲伏安法（DPV）进行了表征。该传感器具有出色的分析性能，线性动态范围（LDR）为100到7500 nM，检测下限（LOD）为2.12（±0.03）nM，这比最近报道的AP传感器要好。最终传感器的实际应用/临床可能性通过加标和回收法对人尿液中的真实样品进行了评估，发现AP回收率在92％至96％之间。传感器探针对共存的干扰分子（如葡萄糖，尿素，尿酸和各种氨基酸）的响应微不足道，而这些干扰分子通常在真实样品中发现（p <0.001，n = 3）。评估了传感器探针的保质期，发现其稳定了8周。使用MWCNT-AuNPs / AuDN制作的传感器探头易于制造，简单，坚固，
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