Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.

中文翻译：

---

转化医学中针对衰老细胞。


机体衰老是一个复杂的过程，会导致组织的功能和再生潜力逐渐受损。细胞衰老是响应损伤和压力而发生的细胞周期稳定停滞的状态，被认为是衰老的标志。衰老细胞在衰老过程中在多个器官中积累，导致组织功能障碍并引起病理表现。因此，衰老是包括癌症在内的多种人类年龄相关疾病的一个决定性特征，而靶向消除这些细胞最近已成为一种有前景的治疗方法，可改善组织损伤并促进修复和再生。此外，衰老细胞的体内鉴定对于多种病理的早期诊断具有巨大潜力。在这里，我们回顾了涉及细胞衰老的临床前治疗策略中使用的现有衰老药物、小分子和药物递送工具，以及追踪衰老细胞的探针。我们还回顾了衰老的临床研究前景，并讨论了识别和靶向细胞衰老如何对病理和衰老过程产生积极影响。