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An NIR-responsive mesoporous silica nanosystem for synergetic photothermal-immunoenhancement therapy of hepatocellular carcinoma.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2019-11-19 , DOI: 10.1039/c9tb01891c
Han Yang 1 , Hong-Sheng Liu 2 , Wen Hou 2 , Jun-Xiao Gao 1 , Yue Duan 1 , Daohe Wei 1 , Xiao-Qun Gong 1 , Han-Jie Wang 1 , Xiao-Li Wu 1 , Jin Chang 1
Affiliation  

To create a more precise, efficient imaging and therapeutic strategy is a big challenge for the current treatment of hepatocellular carcinoma (HCC). Photothermal therapy (PTT) has attracted enormous attention due to its non-invasive property and precise spatial and temporal control. Here, we developed a strategy to realize superior imaging performance and treatment, utilizing an indocyanine green (ICG) and sorafenib (S) co-loaded mesoporous silica nanosystem for synergetic PTT/immuno-enhanced therapy. We proved that (ICG+S)@mSiO2 could be easily endocytosed by H22 cells, carried out outstanding real-time fluorescence imaging, and enhanced cytotoxicity abilities by near-infrared radiation (NIR) in vitro. Moreover, (ICG+S)@mSiO2 also had excellent fluorescence imaging ability, displayed a remarkable photothermal tumor killing effect and immune enhancement capability under 808 nm irradiation in an H22 tumor-bearing mice model, without apparent adverse effects in other organs. This study provides a new strategy for the development of a PTT/immuno-enhanced synergistic theranostic nanosystem of HCC.

中文翻译:

NIR响应介孔二氧化硅纳米系统的肝细胞癌的协同光热免疫增强治疗。

对于当前肝细胞癌(HCC)的治疗,创建更精确,有效的成像和治疗策略是一个巨大的挑战。光热疗法(PTT)由于其无创性和精确的时空控制而备受关注。在这里,我们开发了一种策略,以利用吲哚菁绿(ICG)和索拉非尼(S)共同负载的介孔二氧化硅纳米系统实现协同的PTT /免疫增强疗法,以实现出色的成像性能和治疗。我们证明(ICG + S)@mSiO 2可以很容易地被H22细胞内吞,进行出色的实时荧光成像,并在体外通过近红外辐射(NIR)增强了细胞毒性。此外,(ICG + S)@mSiO 2在具有H22荷瘤的小鼠模型中,其还具有出色的荧光成像能力,在808 nm辐射下显示出显着的光热肿瘤杀伤作用和免疫增强能力,而在其他器官中没有明显的不良作用。这项研究为肝癌的PTT /免疫增强的协同治疗神经系统的发展提供了新的策略。
更新日期:2019-11-19
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