Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles.

中文翻译：

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精神分裂症多基因风险评分对白质微观结构的影响。

精神分裂症 (SZ) 和双相情感障碍 (BD) 具有高度遗传性，具有共同的症状，并具有多基因结构。最近的精神病多基因风险评分（PRS）的影响，结合了多种全基因组相关的风险变异，应该对以前与疾病相关的可遗传脑表型进行评估，以便更好地了解疾病的途径。我们最近报道了当前 SZ PRS 预测第一次精神病病例控制状态和一般认知的能力。在这里，我们使用 141 名参与者（包括 SZ、BP、SZ 或 BP 患者的亲属和健康志愿者）和两名白人，测试其对已知在 SZ、BD 及其亲属中受损的白质微结构的外显率。物质完整性指标：分数各向异性 (FA) 和平均扩散率 (MD)。未发现 SZ PRS 与 FA 或 MD 之间存在显着相关性，因此尚不清楚白质变化是否主要与 SZ 遗传风险谱相关。