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Ecdysone controlled cell and tissue deletion.
Cell Death and Differentiation ( IF 13.7 ) Pub Date : 2019-11-19 , DOI: 10.1038/s41418-019-0456-9
Tianqi Xu 1 , Xin Jiang 1 , Donna Denton 1 , Sharad Kumar 1
Affiliation  

The removal of superfluous and unwanted cells is a critical part of animal development. In insects the steroid hormone ecdysone, the focus of this review, is an essential regulator of developmental transitions, including molting and metamorphosis. Like other steroid hormones, ecdysone works via nuclear hormone receptors to direct spatial and temporal regulation of gene transcription including genes required for cell death. During insect metamorphosis, pulses of ecdysone orchestrate the deletion of obsolete larval tissues, including the larval salivary glands and the midgut. In this review we discuss the molecular machinery and mechanisms of ecdysone-dependent cell and tissue removal, with a focus on studies in Drosophila and Lepidopteran insects.

中文翻译:


蜕皮激素控制细胞和组织的缺失。



去除多余和不需要的细胞是动物发育的关键部分。在昆虫中,类固醇激素蜕皮激素是本次综述的重点,它是发育转变(包括蜕皮和变态)的重要调节剂。与其他类固醇激素一样,蜕皮激素通过核激素受体发挥作用,指导基因转录的空间和时间调节,包括细胞死亡所需的基因。在昆虫变态过程中,蜕皮激素的脉冲会协调淘汰废弃的幼虫组织,包括幼虫唾液腺和中肠。在这篇综述中,我们讨论了蜕皮激素依赖性细胞和组织去除的分子机制和机制,重点是果蝇和鳞翅目昆虫的研究。
更新日期:2019-11-19
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