Microwave‐Assisted Synthesis as an Efficient Method to Enhance the Catalytic Activity of Zr‐Based Metal Organic Framework UiO‐66 in a Heterocyclization Reaction,Asian Journal of Organic Chemistry

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Microwave‐Assisted Synthesis as an Efficient Method to Enhance the Catalytic Activity of Zr‐Based Metal Organic Framework UiO‐66 in a Heterocyclization Reaction
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2019-12-03 , DOI: 10.1002/ajoc.201900556
Linh Ho Thuy Nguyen _{1,

2} , Trang Thi Thu Nguyen _{1,

2} , Y. Thi Dang ₁ , Phuong Hoang Tran ₂ , Tan Le Hoang Doan _{1,

2}

Affiliation

Zr‐based metal‐organic frameworks have been considered promising heterogeneous catalysts in various reactions. It has been proven that the defect sites in these frameworks, which result from deficiency of linkers, could act as the reaction active sites. In this work, microwave irradiation was used for rapid synthesis and increasing defects on Zr₆ clusters of metal‐organic framework UiO‐66. Powder X‐ray diffraction, thermal gravimetric analysis, and N₂ sorption isotherms were performed to characterize and calculate the defect number in the framework. UiO‐66 prepared by microwave method for a few minutes could reach 1.8 missing linkers per cluster. The material with acetic acid as a co‐catalyst showed highly heterogeneous catalytic activity in the solvent‐free heterocyclization of 2,2‐disubstituted 2,3‐dihydroquinazolin‐4(1H)‐ones from anthranilamide and ketones/aldehydes. The synthetic scheme consisted of zirconium cluster catalysed carbonyl group of anthranilamide to achieve the C−N propitious combination and succeeding ring closure process.

中文翻译：

微波辅助合成作为增强Zr基金属有机骨架UiO-66在杂环化反应中的催化活性的有效方法

基于Zr的金属有机骨架已被认为在各种反应中都有望成为非均相催化剂。已经证明，由于缺乏接头而导致的这些构架中的缺陷位点可以充当反应活性位点。在这项工作中，微波辐射被用于快速合成并增加金属有机骨架UiO-66的Zr ₆团簇上的缺陷。粉末X射线衍射，热重分析和N ₂进行吸附等温线表征和计算框架中的缺陷数。通过微波方法制备的UiO-66几分钟，每个簇可能会丢失1.8个连接子。以乙酸为助催化剂的物质在蒽酰胺和酮/醛类中的2,2-二取代的2,3-二氢喹唑啉-4（1 H）-酮的无溶剂杂环化中显示出高度异质的催化活性。该合成方案由锆簇催化的邻氨基苯甲酰胺的羰基组成，以实现CN有利的结合和随后的闭环过程。

更新日期：2019-12-03

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