How cord blood (CB) CD34+ cell content and dose and 8-allele HLA match vary by patient ancestry is unknown. We analyzed cell content, dose, and high-resolution HLA-match of units selected for CB transplantation (CBT) by recipient ancestry. Of 544 units (286 infused, 258 next-best backups) chosen for 144 racially diverse adult patients (median weight, 81 kg), the median total nucleated cell (TNC) and CD34+cell +contents were higher for Europeans than for non-Europeans: 216 × 107versus 197 × 107 (P = .002) and 160 × 105 versus 132 × 105 (P = .007), respectively. There were marked cell content disparities among ancestry groups, with units selected for Africans having the lowest TNC (189 × 107) and CD34+ cell (122 × 105) contents. Units for non-Europeans were also more HLA-mismatched (P = .017). When only the 286 transplanted units were analyzed, the adverse effect of reduced cell content was exacerbated by the higher weights in some groups. For example, northwestern Europeans (high patient weight, high unit cell content) had the best-dosed units, and Africans (high weight, low unit cell content) had the lowest. In Asians, low cell content was partially compensated for by lower weight. Marked differences in 8-allele HLA-match distribution were also observed by ancestry group; for example, 23% of units for northwestern Europeans were 3/8 to 4/8 HLA-matched, compared with 40% for southern Europeans, 46% for white Hispanics, and 51% for Africans. During the study period, 20 additional patients (17 non-Europeans; median weight, 98 kg) did not undergo CBT owing to the lack of a suitable graft. CB extends transplantation access to most patients, but racial disparities exist in cell content, dose, and HLA match.

中文翻译：

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通过患者祖先评估脐带血总有核和 CD34+ 细胞含量、细胞剂量和 8 等位基因 HLA 匹配。

脐带血 (CB) CD34+ 细胞含量和剂量以及 8 等位基因 HLA 匹配如何因患者血统而异尚不清楚。我们分析了按受体血统选择用于 CB 移植 (CBT) 的单元的细胞含量、剂量和高分辨率 HLA 匹配。在为 144 名不同种族的成年患者（中位数体重，81 公斤）选择的 544 个单位（286 个输注，258 个次优备份）中，欧洲人的总有核细胞 (TNC) 和 CD34+细胞 + 含量的中位数高于非-欧洲人：分别为 216 × 107 与 197 × 107 (P = .002) 和 160 × 105 与 132 × 105 (P = .007)。血统之间存在显着的细胞含量差异，为具有最低 TNC (189 × 107) 和 CD34+ 细胞 (122 × 105) 含量的非洲人选择单位。非欧洲人的单位也更不匹配 (P = .017)。当仅分析 286 个移植单元时，某些组中较高的重量会加剧细胞含量减少的不利影响。例如，西北欧人（患者体重高、单位细胞含量高）的剂量单位最好，而非洲人（体重高、单位细胞含量低）的剂量最低。在亚洲人中，较低的细胞含量可以通过较低的体重得到部分补偿。祖先组也观察到 8 等位基因 HLA 匹配分布的显着差异；例如，西北欧人 23% 的单位是 3/8 到 4/8 HLA 匹配，而南欧人为 40%，西班牙裔白人为 46%，非洲人为 51%。在研究期间，另外 20 名患者（17 名非欧洲人；中位数体重，98 公斤）由于缺乏合适的移植物而没有接受 CBT。CB 扩大了对大多数患者的移植机会，但细胞含量存在种族差异，