Collective cell migration does not only reflect the migration of cells at a similar speed and in the same direction, it also implies the emergence of new properties observed at the level of the cell group. This collective behavior relies on interactions between the cells and the establishment of a hierarchy amongst cells with leaders driving the group of followers. Here, we make the parallel between the front-to-rear polarity axis in single cell and the front-to-rear multicellular-scale polarity of a migrating collective which established through exchange of biochemical and mechanical information from the front to the rear and vice versa. Such multicellular-scale polarity gives the migrating group the possibility to better sense and adapt to energy, biochemical and mechanical constraints and facilitates migration over long distances in complex and changing environments.

中文翻译：

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集体迁移中的多细胞尺度从前到后的极性。

集体细胞迁移不仅反映了细胞以相似的速度和相同的方向迁移，而且还暗示了在细胞群水平上观察到的新特性的出现。这种集体行为依赖于单元之间的交互以及在单元之间建立层次结构，并由领导者驱动跟随者组。在这里，我们将单细胞的前后极性轴与迁移集体的前后多细胞尺度极性之间的平行关系建立起来，该集体通过从前向后交换生物化学和机械信息而建立的，反之亦然。反之亦然。这种多细胞尺度的极性为迁移的群体提供了更好地感知和适应能量的可能性，