Abstract In this study, three new Cd(II) coordination polymers, [Cd(TPT)(NO3)2(MeOH)](CH2Cl2) (1), [Cd3(TPT)2(NO3)6(MeOH)4](MeOH)2 (2) and [Cd(TPT)(NO3)2] (3), with structural diversity [from one-dimensional (1D) chain to 3D framework structures] have been prepared by using 2,4,6-tris-(pyridyl)-1,3,5-triazine (TPT) as ligand. The CCK-8 assay was used to explore the anti-proliferation effect of 1–3 on MKN45 gastric cancer cells, Annexin V-FITC/PI assay was performed to confirm the apoptosis and cell cycle arrest of MKN45 in a flow cytometer; the intracellular ROS level was also determined in this study. mRNA expressions of p53, nf-κb, and tnf-α in MKN45 cancer cells after treatment with 1–3 was measured by quantitative reverse transcription polymerase chain reaction. The biological results showed that 1 exerted anticancer activity through inducing apoptosis by upregulating the apoptotic genes and intracellular ROS level.

中文翻译：

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三种 Cd(II) 配位聚合物通过促进细胞内 ROS 积累和凋亡基因表达诱导胃癌细胞凋亡

摘要 在本研究中，三种新型 Cd(II) 配位聚合物 [Cd(TPT)(NO3)2(MeOH)](CH2Cl2) (1)、[Cd3(TPT)2(NO3)6(MeOH)4]( MeOH)2 (2) 和 [Cd(TPT)(NO3)2] (3) 具有结构多样性 [从一维 (1D) 链到 3D 骨架结构] 已通过使用 2,4,6-tris 制备-(吡啶基)-1,3,5-三嗪(TPT)作为配体。CCK-8法检测1-3对MKN45胃癌细胞的抗增殖作用，Annexin V-FITC/PI法检测MKN45在流式细胞仪中的凋亡和细胞周期阻滞；本研究还测定了细胞内 ROS 水平。通过定量逆转录聚合酶链反应测量用 1-3 处理后 MKN45 癌细胞中 p53、nf-κb 和 tnf-α 的 mRNA 表达。