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Hot new structures of the cold sensor, TRPM8, reveal insights into the fundamentals of cold perception and adaptation.
Cell Calcium ( IF 4.3 ) Pub Date : 2019-11-16 , DOI: 10.1016/j.ceca.2019.102112
Fabian Gruss 1
Affiliation  

The ion channel TRPM8 has been identified as the primary cold sensor in humans, but insights into how cold perception is established remained elusive. This has changed now with newly published structures of TRPM8 in different states during channel gating, which help us understand why we feel cold and adapt to it.

中文翻译:

TRPM8是冷传感器的热门新结构,揭示了对冷感知和适应基础的见解。

离子通道TRPM8已被确定为人类的主要感冒传感器,但是对于如何建立冷感的见解仍然难以捉摸。现在,由于在通道门控期间处于不同状态的TRPM8新发布的结构,这种情况已经改变,这有助于我们理解为什么感到冷并适应它。
更新日期:2019-11-18
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