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Axonal dispatch of iron in neuronal signaling.
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2019-12-01 , DOI: 10.1038/s41589-019-0394-3 Peng Lei 1, 2 , Scott Ayton 2 , Ashley I Bush 2
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2019-12-01 , DOI: 10.1038/s41589-019-0394-3 Peng Lei 1, 2 , Scott Ayton 2 , Ashley I Bush 2
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The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by axonal transport of iron in an activity-dependent and unidirectional manner between functionally associated regions. The supply of iron from the ventral hippocampus to the middle prefrontal cortex subserved an anxiolytic phenotype and mediated the neuropharmacological actions of diazepam and lithium chloride in rodent models.
中文翻译：
神经元信号中铁的轴突调度。
Wang 等人报道了脑铁稳态的调节，以前被认为是细胞自主的并由间质液中的局部因素调节。在功能相关区域之间以活动依赖性和单向方式受到铁的轴突运输的强烈影响。在啮齿动物模型中，从腹侧海马向中前额叶皮层供应铁有助于抗焦虑表型并介导地西泮和氯化锂的神经药理学作用。
更新日期：2019-11-18
中文翻译：
神经元信号中铁的轴突调度。
Wang 等人报道了脑铁稳态的调节，以前被认为是细胞自主的并由间质液中的局部因素调节。在功能相关区域之间以活动依赖性和单向方式受到铁的轴突运输的强烈影响。在啮齿动物模型中，从腹侧海马向中前额叶皮层供应铁有助于抗焦虑表型并介导地西泮和氯化锂的神经药理学作用。
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