Pramipexole is a dopamine agonist used as a treatment in PD and restless legs syndrome to reduce motor symptoms, but it often induces impulse control disorders. In particular, patients with impulse control disorders tend to make more impulsive choices in the delay discounting task, that is, they choose small immediate rewards over larger delayed ones more often than patients without impulse control disorders and healthy subjects do. Yet the site of action of pramipexole that produces these impulsive choices remains unknown. Based on the heterogeneity of corticostriatal projections and the massive dopamine innervation of the striatum, we hypothesized that impulsive choices triggered by dopamine treatments may be supported by a specific striatal territory.

中文翻译：

---

前尾状核支持普拉克索触发的冲动选择

普拉克索是一种多巴胺激动剂，用于治疗 PD 和不宁腿综合征以减轻运动症状，但它通常会诱发冲动控制障碍。特别是，冲动控制障碍患者在延迟折扣任务中倾向于做出更多的冲动选择，即他们比没有冲动控制障碍的患者和健康受试者更经常选择较小的即时奖励而不是较大的延迟奖励。然而，普拉克索产生这些冲动选择的作用部位仍然未知。基于皮质纹状体投射的异质性和纹状体的大量多巴胺神经支配，我们假设多巴胺治疗引发的冲动选择可能受到特定纹状体区域的支持。