Seminal work by Oettgen et al.1 in the early 90's revealed the existence of alternative pathways of anaphylaxis (non IgE-mediated) in IgE-deficient mice. These are mediated by IgG-immune complexes which, depending on their nature, signal on a number of myeloid cells including macrophages/monocytes, basophils, mast cells and neutrophils. While extensively characterized in mice, conclusive evidence of the existence of alternative pathways of anaphylaxis in humans have remained elusive.

中文翻译：

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药物诱导的人类 IgG 中性粒细胞介导的过敏反应：发现！

Oettgen 等人 1 在 90 年代初期的开创性工作揭示了在 IgE 缺陷小鼠中存在过敏反应的替代途径（非 IgE 介导）。这些是由 IgG 免疫复合物介导的，根据其性质，IgG 免疫复合物在许多骨髓细胞上发出信号，包括巨噬细胞/单核细胞、嗜碱性粒细胞、肥大细胞和中性粒细胞。虽然在小鼠中得到了广泛的表征，但人类过敏反应替代途径存在的确凿证据仍然难以捉摸。