There is no consensus on the definition of an exaggerated increase in systolic blood pressure (SBP) during exercise. The aim was to explore a potential threshold for exercise SBP associated with increased risk of coronary heart disease in healthy men using repeated exercise testing. Two thousand fourteen healthy white male employees were recruited into the Oslo Ischemia Study during early 1970s. At follow-up 7 years later, 1392 men were still considered healthy. A bicycle exercise test at 100 W workload was performed at both visits. Cox regression analyses were performed with increasing cutoff levels of peak exercise SBP at 100 W workload (SBP100W) from 160 mm Hg to 200 mm Hg, adjusted for cardiovascular risk factors and physical fitness. Participants with SBP100W below cutoff level at both baseline and first follow-up were compared with participants with SBP100W equal to or above cutoff level at both visits. Compared with participants with SBP100W below all cutoff levels between 165 and 195 mm Hg, coronary heart disease risk was increased among participants with SBP100W equal to or above cutoff at all levels. There was no evidence of a distinct threshold level for coronary heart disease risk, and the relation between SBP100W and coronary heart disease appears linear. When investigating exercise SBP at moderate workload measured at 2 exercise tests in healthy middle-aged white men, there is increasing risk of coronary heart disease with increasing exercise SBP independent of SBP at rest. The association is linear from the low range of exercise SBP, and there is no sign of a distinct threshold level for increased coronary disease risk.

中文翻译：

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中等工作负荷下的运动收缩压与健康男性的冠心病风险呈线性相关

运动期间收缩压 (SBP) 过度升高的定义尚未达成共识。目的是通过重复运动测试探索与健康男性冠心病风险增加相关的运动收缩压的潜在阈值。1970 年代初期，2014 名健康的白人男性雇员被招募到奥斯陆缺血研究中。在 7 年后的随访中，1392 名男性仍然被认为是健康的。在两次访问中都进行了 100 W 工作负载的自行车运动测试。Cox 回归分析是在 100 W 工作负荷 (SBP100W) 时将峰值运动 SBP 的截止水平从 160 毫米汞柱增加到 200 毫米汞柱，并根据心血管危险因素和身体健康进行调整。将基线和首次随访时 SBP100W 低于临界值的参与者与两次随访时 SBP100W 等于或高于临界值的参与者进行比较。与 SBP100W 低于 165 至 195 mmHg 的所有临界值的参与者相比，SBP100W 等于或高于所有临界值的参与者的冠心病风险增加。没有证据表明冠心病风险有明显的阈值水平，SBP100W 与冠心病之间的关系呈线性关系。在健康中年白人男性的 2 次运动测试中测量中等负荷下的运动 SBP 时，随着运动 SBP 的增加，与静息时的 SBP 无关，冠心病的风险会增加。这种关联与运动收缩压的低范围呈线性关系，