Emergence of a Bilaterally Symmetric Pattern from Chiral Components in the Planarian Epidermis.,Developmental Cell

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Emergence of a Bilaterally Symmetric Pattern from Chiral Components in the Planarian Epidermis.
Developmental Cell ( IF 10.7 ) Pub Date : 2019-11-18 , DOI: 10.1016/j.devcel.2019.10.021
Cyril Basquin ₁ , Dmitry Ershov ₂ , Noémie Gaudin ₁ , Hanh Thi-Kim Vu ₃ , Bruno Louis ₄ , Jean-François Papon ₅ , Anne-Marie Orfila ₁ , Sarah Mansour ₃ , Jochen Christian Rink ₃ , Juliette Azimzadeh ₁

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Most animals exhibit mirror-symmetric body plans, yet the molecular constituents from which they are formed are often chiral. In planarian flatworms, centrioles are arranged in a bilaterally symmetric pattern across the ventral epidermis. Here, we found that this pattern is generated by a network of centrioles with prominent chiral asymmetric properties. We identify centriole components required for establishing asymmetric connections between centrioles and balancing their effects to align centrioles along polarity fields. SMED-ODF2, SMED-VFL1, and SMED-VFL3 affect the assembly of centriole appendages that tether cytoskeletal connectors to position the centrioles. We further show that the medio-lateral polarization of centrioles relies on mechanisms that are partly distinct on the left and right sides of the planarian body. Our findings shed light on how bilaterally symmetrical patterns can emerge from chiral cellular organizations.

中文翻译：

涡旋表皮中手性成分的双边对称模式的出现。

大多数动物表现出镜像对称的身体结构，但形成它们的分子成分通常是手性的。在涡虫扁虫中，中心粒在腹侧表皮上以双边对称的模式排列。在这里，我们发现这种模式是由具有突出手征不对称特性的中心粒网络生成的。我们确定了在中心粒之间建立不对称连接并平衡其影响以沿极性场对齐中心粒所需的中心粒组件。SMED-ODF2、SMED-VFL1 和 SMED-VFL3 影响中心粒附属物的组装，这些附属物连接细胞骨架连接器以定位中心粒。我们进一步表明，中心粒的中外侧极化依赖于涡虫身体左侧和右侧部分不同的机制。

更新日期：2019-11-18

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