Precisely controlled organisation at the cellular and tissue level is crucial to establish and maintain complex organisms. The atypical cadherins Fat (Ft), Fat2 and Dachsous (Ds) contribute to this organisation by regulating growth and planar cell polarity. Here we describe the recent advances in understanding how these large cadherins coordinate these processes, and discuss additional progress extending their function in regulation of microtubules, migration and disease.

中文翻译：

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细胞和组织组织中的脂肪/ Dachsous家族钙粘着蛋白。

在细胞和组织水平上精确控制组织对于建立和维持复杂的生物至关重要。非典型钙粘蛋白脂肪（Ft），脂肪2和Dachsous（Ds）通过调节生长和平面细胞极性来促进这种组织。在这里，我们描述了了解这些大型钙粘蛋白如何协调这些过程的最新进展，并讨论了扩展其在微管，迁移和疾病调控中功能的其他进展。