Sensory cortical control of movement.,Nature Neuroscience

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Sensory cortical control of movement.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-11-18 , DOI: 10.1038/s41593-019-0536-7
Spyridon K Karadimas _{1,

2} , Kajana Satkunendrarajah _{2,

3} , Alex M Laliberte _{2,

4} , Dene Ringuette _{2,

5} , Iliya Weisspapir ₂ , Lijun Li ₂ , Simon Gosgnach ₆ , Michael G Fehlings _{1,

2}

Affiliation

Walking in our complex environment requires continual higher order integrated spatiotemporal information. This information is processed in the somatosensory cortex, and it has long been presumed that it influences movement via descending tracts originating from the motor cortex. Here we show that neuronal activity in the primary somatosensory cortex tightly correlates with the onset and speed of locomotion in freely moving mice. Using optogenetics and pharmacogenetics in combination with in vivo and in vitro electrophysiology, we provide evidence for a direct corticospinal pathway from the primary somatosensory cortex that synapses with cervical excitatory neurons and modulates the lumbar locomotor network independently of the motor cortex and other supraspinal locomotor centers. Stimulation of this pathway enhances speed of locomotion, while inhibition decreases locomotor speed and ultimately terminates stepping. Our findings reveal a novel pathway for neural control of movement whereby the somatosensory cortex directly influences motor behavior, possibly in response to environmental cues.

中文翻译：

运动的感觉皮层控制。

在我们复杂的环境中行走需要持续的高阶集成时空信息。该信息在体感皮层进行处理，长期以来一直认为它通过源自运动皮层的下行束影响运动。在这里，我们表明初级体感皮层中的神经元活动与自由移动小鼠的运动开始和速度密切相关。使用光遗传学和药物遗传学与体内和体外电生理学相结合，我们提供了来自初级体感皮层的直接皮质脊髓通路的证据，该通路与颈部兴奋性神经元突触并独立于运动皮层和其他脊髓上运动中心调节腰椎运动网络。这条通路的刺激提高了运动速度，而抑制会降低运动速度并最终终止步进。我们的研究结果揭示了一种新的运动神经控制途径，即体感皮层直接影响运动行为，可能是对环境线索的反应。

更新日期：2019-11-18

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