Neurobiological functions of transcriptional enhancers.,Nature Neuroscience

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Neurobiological functions of transcriptional enhancers.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-11-18 , DOI: 10.1038/s41593-019-0538-5
Alex S Nord _{1,

2} , Anne E West ₃

Affiliation

Transcriptional enhancers are regulatory DNA elements that underlie the specificity and dynamic patterns of gene expression. Over the past decade, large-scale functional genomics projects have driven transformative progress in our understanding of enhancers. These data have relevance for identifying mechanisms of gene regulation in the CNS, elucidating the function of non-coding regulatory sequences in neurobiology and linking sequence variation within enhancers to genetic risk for neurological and psychiatric disorders. However, the sheer volume and complexity of genomic data presents a challenge to interpreting enhancer function in normal and pathogenic neurobiological processes. Here, to advance the application of genome-scale enhancer data, we offer a primer on current models of enhancer function in the CNS, we review how enhancers regulate gene expression across the neuronal lifespan, and we suggest how emerging findings regarding the role of non-coding sequence variation offer opportunities for understanding brain disorders and developing new technologies for neuroscience.

中文翻译：

转录增强子的神经生物学功能。

转录增强子是基因表达的特异性和动态模式的基础调控 DNA 元件。在过去的十年中，大规模的功能基因组学项目推动了我们对增强子理解的变革性进展。这些数据与识别中枢神经系统基因调控机制、阐明神经生物学中非编码调控序列的功能以及将增强子内的序列变异与神经和精神疾病的遗传风险联系起来具有相关性。然而，基因组数据的庞大数量和复杂性对解释正常和致病神经生物学过程中的增强子功能提出了挑战。在这里，为了推进基因组规模增强子数据的应用，我们提供了有关当前 CNS 中增强子功能模型的入门知识，

更新日期：2019-11-18

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