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Mapping microglia states in the human brain through the integration of high-dimensional techniques.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-11-18 , DOI: 10.1038/s41593-019-0532-y Roman Sankowski 1, 2 , Chotima Böttcher 3 , Takahiro Masuda 1 , Laufey Geirsdottir 1 , Sagar 4 , Elena Sindram 1 , Tamara Seredenina 5 , Andreas Muhs 5 , Christian Scheiwe 6 , Mukesch Johannes Shah 6 , Dieter Henrik Heiland 6 , Oliver Schnell 6 , Dominic Grün 4, 7 , Josef Priller 3, 8, 9 , Marco Prinz 1, 7, 10
Nature Neuroscience ( IF 21.2 ) Pub Date : 2019-11-18 , DOI: 10.1038/s41593-019-0532-y Roman Sankowski 1, 2 , Chotima Böttcher 3 , Takahiro Masuda 1 , Laufey Geirsdottir 1 , Sagar 4 , Elena Sindram 1 , Tamara Seredenina 5 , Andreas Muhs 5 , Christian Scheiwe 6 , Mukesch Johannes Shah 6 , Dieter Henrik Heiland 6 , Oliver Schnell 6 , Dominic Grün 4, 7 , Josef Priller 3, 8, 9 , Marco Prinz 1, 7, 10
Affiliation
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Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses and contribute to several neurological and psychiatric diseases. Little is known about human microglia and how they orchestrate their highly plastic, context-specific adaptive responses during pathology. Here we combined two high-dimensional technologies, single-cell RNA-sequencing and time-of-flight mass cytometry, to identify microglia states in the human brain during homeostasis and disease. This approach enabled us to identify and characterize a previously unappreciated spectrum of transcriptional states in human microglia. These transcriptional states are determined by their spatial distribution, and they further change with aging and brain tumor pathology. This description of multiple microglia phenotypes in the human CNS may open promising new avenues for subset-specific therapeutic interventions.
中文翻译：
通过整合高维技术绘制人脑小胶质细胞状态图。
小胶质细胞是中枢神经系统的组织驻留巨噬细胞，可协调局部免疫反应并导致多种神经和精神疾病。人们对人类小胶质细胞以及它们在病理过程中如何协调其高度可塑性、特定环境的适应性反应知之甚少。在这里，我们结合了两种高维技术，即单细胞 RNA 测序和飞行时间质谱细胞术，来识别人脑在稳态和疾病期间的小胶质细胞状态。这种方法使我们能够识别和表征人类小胶质细胞中以前未被认识的转录状态谱。这些转录状态由它们的空间分布决定，并且它们随着衰老和脑肿瘤病理而进一步变化。对人类中枢神经系统中多种小胶质细胞表型的描述可能为子集特异性治疗干预开辟有希望的新途径。
更新日期：2019-11-18
中文翻译：
通过整合高维技术绘制人脑小胶质细胞状态图。
小胶质细胞是中枢神经系统的组织驻留巨噬细胞，可协调局部免疫反应并导致多种神经和精神疾病。人们对人类小胶质细胞以及它们在病理过程中如何协调其高度可塑性、特定环境的适应性反应知之甚少。在这里，我们结合了两种高维技术，即单细胞 RNA 测序和飞行时间质谱细胞术，来识别人脑在稳态和疾病期间的小胶质细胞状态。这种方法使我们能够识别和表征人类小胶质细胞中以前未被认识的转录状态谱。这些转录状态由它们的空间分布决定，并且它们随着衰老和脑肿瘤病理而进一步变化。对人类中枢神经系统中多种小胶质细胞表型的描述可能为子集特异性治疗干预开辟有希望的新途径。
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