Background and Purpose- Most aneurysms are a focal manifestation of a systemic condition. Some reports have suggested genetic and environmental factors may play a role in pathogenesis. The aim of the present study was to evaluate the prevalence of intracranial aneurysms (IA) in a large cohort of patients with other systemic vessel aneurysms and dissections (OVAD) and identify potential risk factors for IA in this population. Methods- We defined OVAD as systemic vessel aneurysms, excluding aortic dissections and aneurysms. A cohort of 1.1 million patients was extracted from the population-based cohort from the Korea National Health Insurance Service, which holds almost all medical data including diagnostic codes, procedures, and personal information. Using χ2 or Fisher exact test, the prevalence of the IA concerning OVAD status was analyzed. Results- In OVAD individuals, 25.7% (261/1017) of patients had been concurrently diagnosed with IA. The odds ratios for having concurrent IA in patients with OVAD were 56.31 (95% CI, 48.821-64.949; P=0.000). OVAD patients with dyslipidemia were >7× likely to be affected by IA (adjusted odds ratio, 7.7 [95% CI, 6.59-9.01]; P=0.000). Hypertension, diabetes mellitus, old age (>60 years), and male sex had increased odds for having concurrent IA by 5.89, 3.48, 1.83, and 1.35, respectively. Subgroup analysis with socioeconomic or disability revealed that the prevalence of IA was significantly higher in all groups. Uncertainty regarding the temporal sequence of onset and lack of detail on disease severity and subtype prevented more conclusive results. Conclusions- Patients with OVAD have a higher prevalence of IA than control groups. Therefore, we may approach aneurysms as systemic disease, and further investigations about their pathophysiology must follow.

中文翻译：

---

全身血管性动脉瘤患者颅内动脉瘤的患病率：一项全国队列研究。

背景和目的-大多数动脉瘤是全身性疾病的主要表现。一些报告表明遗传和环境因素可能在发病机理中起作用。本研究的目的是评估大量其他系统性血管动脉瘤和夹层动脉瘤（OVAD）患者的颅内动脉瘤（IA）患病率，并确定该人群中IA的潜在危险因素。方法-我们将OVAD定义为全身性血管瘤，不包括主动脉夹层和动脉瘤。从韩国国民健康保险局的人口研究队列中提取了110万人的队列，该队列包含了几乎所有的医疗数据，包括诊断代码，程序和个人信息。使用χ2或Fisher精确检验，分析了与OVAD状态有关的IA患病率。结果-在OVAD患者中，有25.7％（261/1017）的患者被同时诊断为IA。OVAD患者并发IA的优势比为56.31（95％CI，48.821-64.949; P = 0.000）。患有血脂异常的OVAD患者可能受IA的影响大于7倍（调整后的优势比为7.7 [95％CI，6.59-9.01]； P = 0.000）。高血压，糖尿病，老年（> 60岁）和男性同时并发IA的几率分别增加了5.89、3.48、1.83和1.35。具有社会经济或残疾状况的亚组分析显示，所有组中IA的患病率均显着较高。关于发作的时间顺序的不确定性以及对疾病严重程度和亚型的缺乏详细信息，无法获得更确定的结果。结论-OVAD患者的IA患病率高于对照组。所以，