Background

Green tea is produced from the tea plant Camellia sinensis without fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea constituents, such as anthocyanidins, flavan-3-ols, flavonols, phenolic acids/depsides and caffeine/vitamins, are associated with many biological activities and cell signaling through interactions with specific proteins and signaling pathways.

Scope and approach

Among the activities and pathways induced or mediated by green tea constituents, estrogen action was focused on through a comprehensive literature search.

Key findings and conclusions

Estrogenic activity was evaluated by animal tests, cell assay, ligand-binding assay, protein assay, reporter-gene assay, transcription assay and yeast two-hybrid assay. Furthermore, health benefits, such as bone protection/bone regeneration, cardioprotection and neuroprotection, have been reported as the potential applications of the estrogenic activity of green tea constituents, whereas their anti-estrogenic activity has been discussed in association with cancer treatment and chemoprevention. Controversial results about their mixed estrogenic/anti-estrogenic/non-estrogenic and biphasic activity, and associated toxicity require further detailed studies to clarify the benefits and risks.

中文翻译：

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绿茶成分的雌激素生物活性及其潜在分子机制

背景

绿茶是从茶树茶中未经发酵生产而来的，含有特征成分，与健康促进作用有关，例如生理，免疫，神经和心理作用以及对疾病的保护作用，例如癌症，心血管疾病和糖尿病。儿茶素类，如儿茶素，表儿茶素，没食子儿茶素，表儿茶素-3- ö -gallate和没食子儿茶素-3- ø -gallate和其他绿茶组分，例如花色素，黄烷-3-醇类，黄酮，酚酸/缩酚酸和咖啡因维生素通过与特定蛋白质和信号传导途径的相互作用与许多生物活性和细胞信号传导相关。

范围和方法

在由绿茶成分诱导或介导的活动和途径中，雌激素的作用主要通过全面的文献搜索进行。

主要发现和结论

通过动物试验，细胞试验，配体结合试验，蛋白质试验，报道基因试验，转录试验和酵母双杂交试验评价雌激素活性。此外，据报道，有益健康的益处，例如骨骼保护/骨骼再生，心脏保护和神经保护，是绿茶成分雌激素活性的潜在应用，而与癌症治疗和化学预防有关的抗雌激素活性已被讨论。关于它们的混合雌激素/抗雌激素/非雌激素和双相活性以及相关毒性的有争议的结果需要进一步详细的研究以阐明其益处和风险。