IgA and the intestinal microbiota: the importance of being specific.,Mucosal Immunology

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IgA and the intestinal microbiota: the importance of being specific.
Mucosal Immunology ( IF 7.9 ) Pub Date : 2019-11-18 , DOI: 10.1038/s41385-019-0227-4
Oliver Pabst ₁ , Emma Slack ₂

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Secretory IgA has long been a divisive molecule. Some immunologists point to the mild phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and evolutionary history as grounds for its importance. Further, there is extensive and growing disagreement over the relative importance of affinity-matured, T cell-dependent IgA vs. "natural" and T cell-independent IgA in both microbiota and infection control. As with all good arguments, there is good data supporting different opinions. Here we revisit longstanding questions in IgA biology. We start the discussion from the question of intestinal IgA antigen specificity and critical definitions regarding IgA induction, specificity, and function. These definitions must then be tessellated with the cellular and molecular pathways shaping IgA responses, and the mechanisms by which IgA functions. On this basis we propose how IgA may contribute to the establishment and maintenance of beneficial interactions with the microbiota.

中文翻译：

IgA 和肠道微生物群：特异性的重要性。

分泌型 IgA 长期以来一直是一个分裂分子。一些免疫学家指出 IgA 缺陷的轻度表型可以证明忽略它是合理的，而一些人则认为它的丰富性和进化史是其重要性的基础。此外，在微生物群和感染控制中，亲和力成熟、T 细胞依赖性 IgA 与“天然”和 T 细胞非依赖性 IgA 的相对重要性存在广泛且不断增长的分歧。与所有好的论点一样，有很好的数据支持不同的观点。在这里，我们重新审视 IgA 生物学中长期存在的问题。我们从肠道 IgA 抗原特异性问题和关于 IgA 诱导、特异性和功能的关键定义开始讨论。然后必须将这些定义与形成 IgA 反应的细胞和分子途径进行镶嵌，以及 IgA 发挥作用的机制。在此基础上，我们提出 IgA 如何有助于建立和维持与微生物群的有益相互作用。

更新日期：2019-11-18

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