Biomolecule-polymer conjugates are constructs that take advantage of the functional or otherwise beneficial traits inherent to biomolecules and combine them with synthetic polymers possessing specially tailored properties. The rapid development of novel biomolecule-polymer conjugates based on proteins, peptides, or nucleic acids has ushered in a variety of unique materials, which exhibit functional attributes including thermo-responsiveness, exceptional stability, and specialized specificity. Key to the synthesis of new biomolecule-polymer hybrids is the use of controlled polymerization techniques coupled with either grafting-from, grafting-to, or grafting- through methodology, each of which exhibit distinct advantages and/or disadvantages. In this review, we present recent progress in the development of biomolecule-polymer conjugates with a focus on works that have detailed the use of grafting-from methods employing ATRP, RAFT, or ROMP.

生物分子-聚合物缀合物是利用生物分子固有的功能或其他有益特性并将其与具有特殊定制特性的合成聚合物相结合的构建体。基于蛋白质、肽或核酸的新型生物分子-聚合物缀合物的快速发展催生了各种独特的材料，这些材料表现出包括热响应性、卓越的稳定性和专门的特异性等功能属性。合成新型生物分子-聚合物杂化物的关键是使用受控聚合技术，并结合自接枝、向接枝或通过接枝方法，每种技术都表现出独特的优点和/或缺点。在这篇综述中，我们介绍了生物分子-聚合物缀合物开发的最新进展，重点关注详细介绍了 ATRP、RAFT 或 ROMP 接枝方法的使用的工作。