Sublingual immunotherapy (SLIT) with Japanese cedar (JCe) pollinosis was expected to be effective for Japanese cypress (JCy) pollinosis. However, only a half of JCy pollinosis patients clinically improved. Therefore, we examined the immunological effect of SLIT for JCy pollinosis. Peripheral blood mononuclear cells (PBMCs) from patients with JCe and JCy pollinosis who did and did not receive SLIT were incubated with Cry j 1, Cha o 1 and Cha o 3 antigens. Basophil activation test (BAT) were performed. Production of IL-5 and IL-17 induced by antigens was inhibited in the SLIT group. Cry j 1-specific production of IL-10 was increased, and serum Cry j 1-specific IgE and -IgG4 were elevated. However, Cha o 1- or Cha o 3-specific production of IL-10 and specific IgG4 was not increased. Antigens-specific BAT did not decrease after SLIT. New SLIT with JCe and JCy is needed for patients with combined JCe and JCy pollinosis.

中文翻译：

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日本雪松花粉提取物舌下免疫疗法对日本雪松和日本柏花粉病的合并患者的免疫学效果。

预计日本柏（JCe）花粉症的舌下免疫疗法（SLIT）对于日本柏（JCy）花粉症是有效的。但是，只有一半的JCy花粉症患者在临床上有所改善。因此，我们检查了SLIT对JCy花粉病的免疫学作用。将接受和不接受SLIT的JCe和JCy花粉病患者的外周血单个核细胞（PBMC）与Cry j 1，Chao 1和Chao 3抗原一起孵育。进行了嗜碱性粒细胞活化试验（BAT）。SLIT组抑制了抗原诱导的IL-5和IL-17的产生。IL-10的Cry j 1特异性产生增加，血清Cry j 1特异性IgE和-IgG4升高。但是，IL-10和Chao-3特异性产生的IL-10和特异性IgG4没有增加。SLIT后抗原特异性BAT并未降低。