Parcellation of the orbitofrontal cortex, anterior cingulate cortex, and inferior frontal gyrus based on their functional connectivity with the whole brain in resting state fMRI with 654 participants was performed to investigate how these regions with different functions in reward, emotion and their disorders are functionally connected to each other and to the whole brain. The human medial and lateral orbitofrontal cortex, the ventromedial prefrontal cortex, the anterior cingulate cortex, and the right and left inferior frontal gyrus have different functional connectivity with other brain areas and with each other; and each of these regions has several parcels with different functional connectivity with other brain areas. In terms of functional connectivity, the lateral orbitofrontal cortex extends especially on the right into the orbital part of the inferior frontal gyrus and provides connectivity with premotor cortical areas. The orbitofrontal cortex, especially the lateral orbitofrontal cortex, has connectivity not only with language-related areas in the inferior frontal gyrus (Broca's area), but also with the angular and supramarginal gyri. In this context, whereas the connectivity of the orbitofrontal cortex, ventromedial prefrontal cortex, and anterior cingulate cortex is symmetrical, the connectivity of the inferior frontal gyrus triangular and opercular parts is asymmetrical for the right and the left hemispheres. These findings have implications for understanding the neural bases of human emotion and decision-making, and for their disorders including depression.

中文翻译：

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人类眶额皮质，前扣带回皮质和额下回的功能连接。

基于654名参与者的静止状态fMRI，基于它们与全脑的功能连通性，对眶额皮质，前扣带回皮质和额下下部进行了区分开，以研究这些在奖励，情感及其障碍方面具有不同功能的区域之间的功能联系彼此和整个大脑。人的内侧和外侧眶额皮层，腹侧前额叶皮层，前扣带回皮层以及左右额额下回与其他大脑区域以及彼此之间具有不同的功能连通性；这些区域中的每个区域都有几个包裹，这些包裹与其他大脑区域具有不同的功能连通性。在功能连接方面，眼眶额叶外侧皮层特别是在右侧延伸到额额下回的眼眶部分，并提供与运动前皮层区域的连通性。眶额皮层，特别是外侧眶额皮层，不仅与下额回的语言相关区域（Broca's区域）相关，而且与角和上颌回也具有连通性。在这种情况下，眼眶额叶皮质，腹膜前额叶皮质和前扣带回皮质的连通性是对称的，而下额回回三角和可操作部分的连通性对于左右半球是不对称的。这些发现对于理解人类情绪和决策的神经基础，以及包括抑郁症在内的疾病具有重要意义。