In recent years, multiple lines of evidence from human genetic and molecular studies have highlighted the importance of the autophagy lysosomal pathway (ALP) in Parkinson's disease (PD). Genes such as GBA and LRRK2, which harbor some of the most common mutations associated with PD, have essential roles in the ALP. α-synuclein, encoded by the SNCA gene, is degraded mainly by the ALP, and mutations/multiplications in SNCA may lead to impairment of chaperone mediated autophagy or other ALP functions. Numerous other PD-related genes, such as PRKN, PINK1, TMEM175, SMPD1, CTSD, CTSB and many more, have also been reported to have important roles in the ALP. Understanding the relationship between ALP impairment and PD pathogenesis may be crucial for uncovering the mechanisms underlying PD, and for the development of long-awaited neuroprotective therapies. In this review, we will discuss the data linking the ALP to PD (other, atypical forms of Parkinsonism, will not be discussed in this review). We will focus on evidence from studies on specific genes and proteins, their roles in the ALP, and the potential mechanisms underlying the involvement of these genes in PD.

近年来，来自人类遗传和分子研究的多条证据强调了自噬溶酶体途径（ALP）在帕金森氏病（PD）中的重要性。带有一些与PD相关的最常见突变的基因，例如GBA和LRRK2，在ALP中具有重要作用。SNCA基因编码的α-突触核蛋白主要被ALP降解，并且SNCA中的突变/繁殖可能导致伴侣蛋白介导的自噬或其他ALP功能的损害。许多其他与PD相关的基因，例如PRKN，PINK1，TMEM175，SMPD1，CTSD，CTSB据报道在ALP中也起着重要作用。了解ALP损伤与PD发病机制之间的关系对于发现PD的潜在机制以及期待已久的神经保护疗法的发展可能至关重要。在本文中，我们将讨论将ALP与PD关联的数据（其他非典型形式的帕金森病，将不在本文中讨论）。我们将重点研究特定基因和蛋白质，它们在ALP中的作用以及这些基因参与PD的潜在机制的研究证据。