Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerational and transgenerational changes in metabolic and brain function of the offspring. Most research has focused on maternal epigenetic and gestational effects; however, paternal contributions are likely to be substantial. We focus on the latest advances in understanding the mechanisms of epigenetic inheritance of obesity-evoked metabolic and neurobiological changes through the paternal germline that predict wide-ranging consequences for the following generation(s).

中文翻译：

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饮食诱导的精子表观基因组程序代谢和行为的改变

在全球范围内，肥胖症已达到流行程度。超重人数迅速增加的原因可以追溯到过度消费高能量、劣质食物以及缺乏身体活动。这一发展具有深远而昂贵的影响。肥胖不仅与严重的生理和心理并发症有关，而且越来越多的证据还表明，通过表观遗传变化会产生连锁反应。父母肥胖可引起后代代谢和脑功能的代际和跨代变化。大多数研究都集中在母体表观遗传和妊娠效应上；然而，父亲的贡献可能很大。