Porcine reproductive and respiratory syndrome virus (PRRSV) dramatically affects the thymus and its ability to carry out its normal functions. In particular, infection incapacitates PRRSV-susceptible CD14pos antigen-presenting cells (APCs) in the thymus and throughout the body. PRRSV-induced autophagy in thymic epithelial cells modulates the development of T cells, and PRRSV-induced apoptosis in CD4posCD8pos thymocytes modulates cellular immunity against PRRSV and other pathogens. Pigs are less able to resist and/or eliminate secondary infectious agents due the effect of PRRSV on the thymus, and this susceptibility phenomenon is long recognized as a primary characteristic of PRRSV infection.

中文翻译：

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PRRSV感染对猪胸腺的影响。

猪繁殖与呼吸综合症病毒（PRRSV）极大地影响了胸腺及其执行其正常功能的能力。特别是，感染会使胸腺和整个身体中PRRSV易感的CD14pos抗原呈递细胞（APC）失去能力。胸腺上皮细胞中PRRSV诱导的自噬调节了T细胞的发育，而CD4posCD8pos胸腺细胞中PRRSV诱导的凋亡调节了针对PRRSV和其他病原体的细胞免疫。猪由于PRRSV对胸腺的作用而抵抗和/或消除继发感染因子的能力较弱，这种敏感性现象长期以来被认为是PRRSV感染的主要特征。