Axonal transport is critical for neuronal homeostasis and relies on motor complexes bound to cargoes via specific adaptors. However, the mechanisms responsible for the spatiotemporal regulation of axonal transport are not completely understood. A recent study by Liao et al. contributes to filling this gap by reporting that RNA granules 'hitchhike' on LAMP1-positive organelles using annexin A11 as a tether.

中文翻译：

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一起旅行：ALS 的统一病理机制

轴突运输对于神经元稳态至关重要，并依赖于通过特定适配器与货物结合的运动复合物。然而，负责轴突运输时空调节的机制尚不完全清楚。Liao 等人最近的一项研究。通过报告使用膜联蛋白 A11 作为系链的 LAMP1 阳性细胞器上的 RNA 颗粒“搭便车”，有助于填补这一空白。