This report describes transmission of a Burkholderia cenocepacia ET12 strain (ET12-Bc) at the Toronto Adult Cystic Fibrosis (CF) Centre occurring from 2008 to 2017. Epidemiological and genomic data from 11 patients with CF were evaluated. Isolates were analysed using whole genome sequencing (WGS). Epidemiological investigation and WGS analysis suggested nosocomial transmission, despite enhanced infection control precautions. This was associated with subsequent deaths in 10 patients. ET12-Bc positive patients are no longer cared for on the same unit as ET12-Bc negative patients.

中文翻译：

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Burkholderia cenocepacia ET12 在成人囊性纤维化中的传播

本报告描述了 2008 年至 2017 年在多伦多成人囊性纤维化 (CF) 中心发生的一种伯克霍尔德氏菌 ET12 菌株 (ET12-Bc) 的传播。评估了 11 名 CF 患者的流行病学和基因组数据。使用全基因组测序 (WGS) 分析分离物。流行病学调查和 WGS 分析表明，尽管加强了感染控制预防措施，但仍存在院内传播。这与随后 10 名患者的死亡有关。ET12-Bc 阳性患者不再与 ET12-Bc 阴性患者在同一病房接受治疗。