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Osteoporosis in the lower extremities in chronic spinal cord injury.
Spinal Cord ( IF 2.1 ) Pub Date : 2019-11-15 , DOI: 10.1038/s41393-019-0383-0
Angela Frotzler 1 , Jörg Krebs 1 , Andrea Göhring 2 , Kathrin Hartmann 3 , Stefanie Tesini 1 , Kurt Lippuner 4
Affiliation  

Study design

Cross-sectional study.

Objectives

To investigate the effect of chronic motor complete spinal cord injury (SCI) and sex on bone densitometry parameters of the hip, femoral neck, tibial epiphysis, and diaphysis and on long bone fractures.

Setting

SCI rehabilitation center.

Methods

Women and men with long-term (≥7 years) motor complete SCI were compared with able-bodied women and men. Dual-energy X-ray absorptiometry was used to assess bone densitometry parameters at the hip and femoral neck, whereas peripheral quantitative computed tomography was used for the tibial epiphysis and diaphysis.

Results

The data of 18 women and 25 men with SCI with a mean age of 54.7 ± 12.4 and 53.5 ± 8.6 years, respectively, were analyzed. As reference groups, 74 able-bodied women and 46 men with a mean age of 51.0 ± 13.1 and 50.9 ± 11.2 years were evaluated. Most bone densitometry values were significantly (p ≤ 0.033) lower in the SCI compared with the reference groups, including total bone mineral density at the distal tibial epiphysis (−58.0% in SCI women and −53.6% in SCI men). Fracture rates per 100 patient-years were 3.17 and 2.66 in women and men with SCI compared with 0.85 and 0.21 in able-bodied women and men, respectively.

Conclusions

Compared with able-bodied women and men, individuals with chronic motor complete SCI showed considerably lower bone densitometry values and a higher historical fracture rate. These findings support the need for preventative and therapeutic strategies against bone loss in individuals with SCI.



中文翻译:

下肢骨质疏松症是慢性脊髓损伤。

学习规划

横断面研究。

目标

为了研究慢性运动完全性脊髓损伤(SCI)和性别对髋部,股骨颈,胫骨骨physi和骨干和骨干的骨密度测定参数以及长骨骨折的影响。

环境

SCI康复中心。

方法

长期(≥7年)运动完全性脊髓损伤的男女与健壮的男女进行比较。双能X线骨密度仪用于评估髋部和股骨颈的骨密度参数,而外周定量计算机体层摄影术用于胫骨骨epi和骨干。

结果

分析了18名SCI的女性和25名男性的平均年龄,分别为54.7±12.4和53.5±8.6岁。作为参考组,评估了74名健康女性和46名男性,平均年龄为51.0±13.1和50.9±11.2岁。最骨密度值均显著(p  ≤0.033)下在SCI与基准组,包括在总骨矿物质密度相比,胫骨远端骨骺(-58.0%在SCI女性和男性SCI -53.6%)。患有SCI的女性和男性每100个病人年的骨折率分别为3.17和2.66,而身体健全的女性和男性分别为0.85和0.21。

结论

与健全的男女相比,患有慢性运动完全性脊髓损伤的个体显示出较低的骨密度值和较高的历史骨折率。这些发现支持需要针对SCI患者预防和治疗骨质流失的策略。

更新日期:2019-11-15
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