Nanotechnology-Based Diagnostics and Therapy for Pathogen-Related Infections in the CNS.,ACS Chemical Neuroscience

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Nanotechnology-Based Diagnostics and Therapy for Pathogen-Related Infections in the CNS.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2019-11-14 , DOI: 10.1021/acschemneuro.9b00470
Subramanian Tamil Selvan ₁ , Parasuraman Padmanabhan ₁ , Balázs Zoltán Gulyás ₁

Affiliation

The central nervous system (CNS) encompasses the brain, spinal cord, and nerves, where both brain and spinal cord are safeguarded by the meninges. However, serious bacterial, viral, or fungal infection in the brain causes life-threatening diseases such as meningitis. Engineered nanostructures hold great promise for not only in the diagnosis but also for combating microbial drug resistance owing to their high surface area and innate antibacterial activity. We delineate several nanoparticle-based approaches to enhance the CNS delivery of drugs across the blood-brain barrier (BBB). While pathogens invade the CNS by phagocytosis or receptor (e.g., EphA2)-mediated transcytosis, most of the nanoparticles cross the BBB via receptor-mediated transcytosis (e.g., antibody, peptide, protein). We also provide our perspectives on the diagnostic pathways based on nanotechnology for the detection of pathogens in the brain, thereby opening up new therapeutic avenues.

中文翻译：

基于纳米技术的中枢神经系统病原相关感染的诊断和治疗。

中枢神经系统（CNS）涵盖大脑，脊髓和神经，其中脑膜可保护大脑和脊髓。但是，大脑中严重的细菌，病毒或真菌感染会导致威胁生命的疾病，例如脑膜炎。工程纳米结构由于其高的表面积和固有的抗菌活性，不仅在诊断方面而且在抵抗微生物耐药性方面都具有广阔的前景。我们描述了几种基于纳米颗粒的方法，以增强跨血脑屏障（BBB）的中枢神经系统药物传递。当病原体通过吞噬作用或受体（例如EphA2）介导的胞吞作用侵入CNS时，大多数纳米颗粒通过受体介导的胞吞作用（例如抗体，肽，蛋白质）穿过BBB。

更新日期：2019-11-14

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