Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors.,Chemical Reviews

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Disease Detection with Molecular Biomarkers: From Chemistry of Body Fluids to Nature-Inspired Chemical Sensors.
Chemical Reviews ( IF 51.4 ) Pub Date : 2019-11-15 , DOI: 10.1021/acs.chemrev.9b00437
Yoav Y Broza ₁ , Xi Zhou ₂ , Miaomiao Yuan ₃ , Danyao Qu ₄ , Youbing Zheng ₁ , Rotem Vishinkin ₁ , Muhammad Khatib ₁ , Weiwei Wu ₄ , Hossam Haick _{1,

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Affiliation

This article aims to review nature-inspired chemical sensors for enabling fast, relatively inexpensive, and minimally (or non-) invasive diagnostics and follow-up of the health conditions. It can be achieved via monitoring of biomarkers and volatile biomarkers, that are excreted from one or combination of body fluids (breath, sweat, saliva, urine, seminal fluid, nipple aspirate fluid, tears, stool, blood, interstitial fluid, and cerebrospinal fluid). The first part of the review gives an updated compilation of the biomarkers linked with specific sickness and/or sampling origin. The other part of the review provides a didactic examination of the concepts and approaches related to the emerging chemistries, sensing materials, and transduction techniques used for biomarker-based medical evaluations. The strengths and pitfalls of each approach are discussed and criticized. Future perspective with relation to the information and communication era is presented and discussed.

中文翻译：

使用分子生物标记物进行疾病检测：从体液化学到自然化学传感器。

本文旨在回顾受自然启发的化学传感器，以实现快速，相对便宜且微不足道的（或非侵入性的）健康状况诊断和随访。它可以通过监测从一种或多种体液（呼吸，汗液，唾液，尿液，精液，乳头抽吸液，眼泪，粪便，血液，组织液和脑脊液）中排出的生物标志物和挥发性生物标志物来实现。）。审查的第一部分提供了与特定疾病和/或采样来源相关的生物标志物的最新汇编。审查的另一部分对与用于基于生物标志物的医学评估中的新兴化学，传感材料和转导技术有关的概念和方法进行了教学检查。讨论和批评了每种方法的优点和缺点。提出并讨论了与信息和通信时代有关的未来观点。

更新日期：2019-11-15

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