Cardiac autophagy inhibitory factor (CAIF) is a novel lncRNA with protective effects on myocardial infarction. We explored the involvement of CAIF in end-stage cardiomyopathy. Patients with end-stage cardiomyopathy and healthy volunteers were included in this study. Myocardial tissues and serum were collected. CAIF was detected by RT-qPCR. ROC curve was used for diagnostic analysis. Prognostic value of CAIF expression for end-stage cardiomyopathy was evaluated by survival curve analysis. Correlations between CAIF expression and clinicopathological data of patients with end-stage cardiomyopathy were analysed by chi-square test. Downregulated CAIF was observed in end-stage cardiomyopathy patients than in healthy controls. CAIF expression distinguished end-stage cardiomyopathy patients from healthy controls and predict the survival of patients. LncRNA CAIF was downregulated in end-stage cardiomyopathy and may serve as a promising prognostic and diagnostic marker for this disease.

心脏自噬抑制因子（CAIF）是一种新型lncRNA，对心肌梗塞具有保护作用。我们探讨了CAIF在终末期心肌病中的作用。终末期心肌病患者和健康志愿者纳入本研究。收集心肌组织和血清。通过RT-qPCR检测到CAIF。ROC曲线用于诊断分析。通过生存曲线分析评估CAIF表达对终末期心肌病的预后价值。通过卡方检验分析CAIF表达与终末期心肌病患者临床病理数据之间的相关性。与健康对照组相比，终末期心肌病患者的CAIF降低。CAIF表达可将终末期心肌病患者与健康对照区分开来，并预测患者的存活率。