Purpose: VAP-1 plays a crucial role in inflammation, oxidative stress and endothelial dysfunction which are main pathophysiologic mechanisms for gestational diabetes. We aimed to determine serum VAP-1 levels, assess its diagnostic value and correlation with clinical parameters in gestational diabetes.

Methods: A total of 60 pregnant women with gestational diabetes and 75 healthy pregnant women between 24–28th gestational weeks between January–June 2017 were included. Pregnant women were screened for gestational diabetes by two-step protocol. Demographic, clinical and laboratory parameters of patients were recorded. VAP-1 was measured using an enzyme-linked immunosorbent assay method.

Results: Gestational diabetes group had higher fasting and postprandial glucose, HbA1c, neutrophil-to-lymphocyte-ratio, platelet-to-lymphocyte-ratio, plateletcrit and C-reactive protein. Furthermore, VAP-1 levels were higher in gestational diabetes (3.35 ± 1.52 vs 2.2 ± 0.74; p < 0.001). VAP-1 levels >2.315 could predict gestational diabetes with a sensitivity of 70% and specificity of 65.3%. VAP-1 was correlated with clinical follow-up parameters such as fasting glucose (r = 0.473, p < 0.001), postprandial glucose (r = 0.416, p < 0.001), HbA1c (r = 0.462, p < 0.001) and inflammatory biomarkers such as platelet-to-lymphocyte-ratio (r = 0.254, p = 0.04), neutrophil-to-lymphocyte-ratio (r = 0.375, p = 0.003) and C-reactive protein (r = 0.306, p = 0.017).

Conclusions: Elevated VAP-1 levels in gestational diabetes correlated with clinical follow-up and inflammatory markers may suggest the pathogenetic role of VAP-1 in gestational diabetes. Hence, we think that VAP-1 could be a promising marker for the prediction of gestational diabetes.

目的： VAP-1在炎症，氧化应激和内皮功能障碍中起着至关重要的作用，而炎症，氧化应激和内皮功能障碍是妊娠糖尿病的主要病理生理机制。我们旨在确定血清VAP-1水平，评估其在妊娠糖尿病中的诊断价值和与临床指标的相关性。

方法：纳入2017年1月至6月的第24至28个孕周之间的60名妊娠糖尿病孕妇和75名健康孕妇。通过两步方案对孕妇进行了妊娠糖尿病筛查。记录患者的人口统计学，临床和实验室参数。使用酶联免疫吸附测定法测量VAP-1。

结果：妊娠糖尿病组的空腹和餐后血糖，HbA1c，嗜中性粒细胞与淋巴细胞之比，血小板与淋巴细胞之比，血小板压积和C反应蛋白较高。此外，妊娠糖尿病患者的VAP-1水平较高（3.35±1.52 vs 2.2±0.74；p  <0.001）。VAP-1水平> 2.315可以预测妊娠糖尿病，其敏感性为70％，特异性为65.3％。VAP-1与临床随访参数相关，例如空腹血糖（r  = 0.473，p  <0.001），餐后葡萄糖（r  = 0.416，p  <0.001），HbA1c（r  = 0.462，p  <0.001）和炎症生物标志物例如血小板与淋巴细胞的比例（r  = 0.254，p  = 0.04），中性粒细胞与淋巴细胞的比例（r  = 0.375，p  = 0.003）和C反应蛋白（r  = 0.306，p  = 0.017）。

结论：妊娠糖尿病中VAP-1水平升高与临床随访有关，炎性标志物可能提示VAP-1在妊娠糖尿病中的致病作用。因此，我们认为VAP-1可能是预测妊娠糖尿病的有前途的标志物。