We are grateful to Di Cosimo, Torri, and Porcu for their valuable comment on our article. We showed that the presence of circulating tumor cells (CTCs) as assessed 2 years after chemotherapy was prognostic for poor disease-free survival (DFS) and overall survival (OS). Di Cosimo et al. raise the question of clinical relevance of this finding by recalculating positive and negative predictive values for a 0- to 40-month interval.

中文翻译：

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对Di Cosimo，Torri和Porcu的回应。

我们感谢Di Cosimo，Torri和Porcu对我们的文章提出了宝贵的意见。我们显示，化疗后2年评估的循环肿瘤细胞（CTC）的存在可预示不良的无病生存期（DFS）和总体生存期（OS）。Di Cosimo等。通过在0到40个月的时间间隔内重新计算阳性和阴性预测值，提出了这一发现与临床相关性的问题。