Two new sesquiterpenes, named carpabrotalactone A (1) and B (2), together with six known sesquiterpenes, 11(13)-dehydroivaxillin (3), eriolin (4), 2α,5α-dihydroxy-11αH-eudesma-4(15)-en-12,8β-olide (5), (5α)-5-hydroxyasperilin (6), 1α,4α-dihydroxy-guaia-11(13)-ene-12,8α-olide (7) and 4α,5α-dihydroxy-guaia-11(13)-en-12,8α-lactone (8), were isolated from the herbs of Carpesium abrotanoides L. The structures of these sesquiterpenes were elucidated based on spectroscopic analysis, and single crystal X-ray diffraction analysis. All the compounds exhibited potent cytotoxicity against the ISK, Hela, A549, Sw620, RBE and Caco-2 cell lines, with IC₅₀ values ranging from 7.8–47.4 μM. In addition, compounds 2, 3, 4, 7 and 8 displayed significant anti-influenza A (H1N1) virus activity with IC₅₀ values of 6.2, 11.6, 16.4, 1.3 and 0.4 μM, respectively.

两个新的倍半萜烯，分别命名为carpabrotalactone A（1）和B（2），以及六个已知的倍半萜烯，11（13）-脱氢伊西林（3），eriolin（4），2α，5α-dihydroxy-11αH-eudesma-4（15） ）-en-12,8β-内酰胺（5），（5α）-5-羟基asperilin （6），1α，4α-二羟基-guaia-11（13）-ene-12,8α-内酰胺（7）和4α，从阿布罗塔角Carpesium abrotanoides的草药中分离出5α-dihydroxy-guaia-11（13）-en-12,8α-内酯（8）L.基于光谱分析和单晶X射线衍射分析阐明了这些倍半萜的结构。所有的化合物显示出强的细胞毒性对抗ISK，Hela细胞，A549，SW620，RBE和Caco-2细胞系，用IC ₅₀值范围为7.8-47.4 μ M.另外，化合物2，3，4，7和8显示的显著抗流感A（H1N1）病毒具有活性的IC _50倍为6.2，11.6，16.4，1.3和0.4的值μ分别男，。