Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. In this context, the present review in which a panel of 13 experts in immunology, dermatology, rheumatology, neurology, hematology, infectious diseases, hepatology, cardiology, ophthalmology and oncology have been involved, puts in common the mechanisms through which IL-17 is considered a molecular target for the development of novel biological therapies in these different fields. A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders, non alcoholic fatty liver disease, multiple sclerosis, inflammatory bowel disease, uveitis, hematological and solid cancer. Current controversies are presented giving an opening line for future research.

中文翻译：

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白细胞介素（IL）-17在炎症和免疫性疾病中的关键作用：聚焦于争议的证据的最新综述。

白介素17（IL-17）是一种促炎性细胞因子，由于其在许多医学专业的不同疾病的发病机理中起着至关重要的作用，因此一直是深入研究的重点。在此背景下，由13位免疫学，皮肤病学，风湿病学，神经病学，血液学，传染病，肝病学，心脏病学，眼科和肿瘤学专家组成的专家组共同探讨了IL-17的机制。被认为是在这些不同领域中开发新型生物疗法的分子靶标。对文献的全面回顾和对最杰出证据的分析，为讨论与治疗各种疾病（例如牛皮癣，牛皮癣性关节炎，类风湿关节炎，强直性脊柱炎，心血管疾病，非酒精性脂肪肝疾病，多发性硬化症，炎症性肠病，葡萄膜炎，血液学和实体癌。提出了当前的争议，为将来的研究开辟了道路。