The RSDL® (Reactive Skin Decontamination Lotion) Kit contains a lotion-impregnated sponge extensively studied for the removal or neutralization of chemical warfare agents from skin. Pilot investigation of efficacy with industrial threat compounds noted that synthetic opioid fentanyl citrate was removed by the RSDL Kit but not chemically inactivated by the lotion. This implies that after use the RSDL Kit will contain intact fentanyl, which may pose a dermal health hazard if the fentanyl is then transferred to skin after use without proper handling. This in vitro investigation studied the contaminated RSDL Kit using three different concentrations of fentanyl with a skin contact time of 15 minutes under direct interaction from passive contact, light touch, and leaning with one hand. It was demonstrated that the expected transfer of fentanyl from contaminated RSDL depends on 1) the concentration of fentanyl and 2) the area of the exposed surface. From a toxicological perspective, the contact risk of fentanyl under the conditions tested can be considered low but not absent. The present study determined that a contaminated RSDL Kit, used for removal of fentanyl, should be handled with proper care. Use of protective gloves in operational use and washing skin afterwards is advised to prevent undesired contamination.

中文翻译：

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芬太尼污染 RSDL® 试剂盒的接触转移风险

RSDL®（反应性皮肤去污乳液）套件包含经过广泛研究的乳液浸渍海绵，用于去除或中和皮肤上的化学战剂。对工业威胁化合物功效的初步调查指出，合成的阿片类芬太尼柠檬酸盐被 RSDL 试剂盒去除，但未被洗剂化学灭活。这意味着 RSDL 试剂盒在使用后将包含完整的芬太尼，如果芬太尼在使用后未经适当处理而转移到皮肤上，可能会对皮肤健康造成危害。这项体外研究使用三种不同浓度的芬太尼，在被动接触、轻触和单手倾斜的直接相互作用下，皮肤接触时间为 15 分钟，研究了受污染的 RSDL 试剂盒。结果表明，芬太尼从受污染的 RSDL 中的预期转移取决于 1) 芬太尼的浓度和 2) 暴露表面的面积。从毒理学角度来看，芬太尼在测试条件下的接触风险可以被认为是低的，但并非没有。本研究确定用于去除芬太尼的受污染 RSDL 试剂盒应妥善处理。建议在操作中使用防护手套并在之后清洗皮肤以防止意外污染。应妥善处理。建议在操作中使用防护手套并在之后清洗皮肤以防止意外污染。应妥善处理。建议在操作中使用防护手套并在之后清洗皮肤以防止意外污染。